PacBio and DNAstack announced the launch of the HiFi Solves Global Consortium, a federated platform that aggregates HiFi whole‑genome sequencing data from nearly 30 clinical and research institutions in 15 countries. The consortium, hosted by DNAstack, currently links more than 10,000 HiFi whole‑genome sequences and is designed to support rare‑disease research without centralizing protected data.
The platform’s scale and diversity give researchers unprecedented statistical power. By harmonizing data and metadata across institutions, the consortium enables secure, privacy‑preserving queries that can identify pathogenic variants in rare diseases more efficiently than siloed studies. The initiative also demonstrates the growing importance of federated data models in genomics, where data sovereignty and regulatory compliance are critical.
Christian Henry, CEO of PacBio, said, "By partnering with DNAstack, we are extending the power of HiFi sequencing beyond individual institutions — enabling secure, federated analysis at global scale while maintaining local data control. This combination of technological precision and international collaboration strengthens variant interpretation and accelerates discoveries for patients with rare disease." The quote underscores PacBio’s strategy to broaden the clinical impact of its HiFi long‑read technology while preserving institutional control over sensitive data.
PacBio’s Q4 2025 results provide context for the consortium launch. Revenue rose 13.8% year‑over‑year to $44.65 million, beating analyst estimates of $43.04 million. The company’s non‑GAAP gross margin expanded to 40% from 31% in the prior year, driven by a stronger mix of instrument ($17.3 million) and consumable ($21.6 million) sales. Operating expenses fell sharply to $57.8 million from $163.1 million, reflecting disciplined cost management. Christian Henry noted that revenue grew 14% YoY and 16% sequentially, highlighting sustained demand for PacBio’s sequencing solutions.
The consortium launch, coupled with solid financial performance, positions PacBio to accelerate rare‑disease discoveries while reinforcing its competitive advantage in the long‑read sequencing market. DNAstack’s cloud‑based genomic data platform, founded in 2014, adds expertise in secure data sharing, making the partnership a powerful model for future federated research initiatives.
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